Relation between Maternal and Neonatal Serum Lipid Profile and Their Impact on Birth Weight

Tamer A. Abdel-Hamid; Dalia AbdelLatif; Eman Ahmed; Mazen Abdel-Rasheed; Ahmed A-Mageed

doi:10.1055/s-0040-1721690

American Journal of Perinatology, Table of Contents

Am J Perinatol 2022; 39(10): 1112-1116
DOI: 10.1055/s-0040-1721690

Original Article

Relation between Maternal and Neonatal Serum Lipid Profile and Their Impact on Birth Weight

Authors

Tamer A. Abdel-Hamid

¹Pediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt
Dalia AbdelLatif

¹Pediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt
Eman Ahmed

²Pediatrics Department, Alhayat Hospital, Alhayat, Egypt
Mazen Abdel-Rasheed

³Reproductive Health Research Department, National Research Centre, Egypt
Ahmed A-Mageed

⁴Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Abstract

Objective Maternal malnutrition with disturbed lipid metabolism during pregnancy may affect the fetal lipid profile. We aimed to detect the relation between maternal and neonatal serum lipid profile, as well as to detect the serum lipid profile difference between small for gestational age (SGA) infants and appropriate for gestational age (AGA) infants to disclose the impact of maternal malnutrition on birth weight.

Study Design A cross-sectional study was conducted on 150 pregnant women coming to the labor room. Before delivery, maternal serum levels of high-density lipoprotein (HDL), low density lipoprotein (LDL), triglycerides (TGs), and total cholesterol were assessed, then after delivery, cord blood samples were taken for assessment of the neonatal lipid profile. Birth weights were measured, then the neonates were divided into SGA and AGA groups.

Results Serum levels of LDL, TGs, and total cholesterol in the SGA infants were lower than that in the AGA infants. A positive correlation between maternal and neonatal serum TGs levels was found. Besides, there was a positive correlation between birth weight and maternal serum levels of LDL, TGs, and total cholesterol.

Conclusion Maternal serum lipid profile could be an indicator of the neonatal serum lipid profile and birth weight.

Key Points

SGA neonates have lower levels of serum lipids compared to AGA neonates.
There is a positive correlation between maternal and neonatal triglycerides.
There is a positive correlation between birth weight and maternal serum lipids.

Keywords

total cholesterol - triglycerides - LDL - HDL - small for gestational age - birth weight

Full Text

References

References
1 Herrera E, Ortega-Senovilla H. Lipid metabolism during pregnancy and its implications for fetal growth. Curr Pharm Biotechnol 2014; 15 (01) 24-31
2 Leiva A, Guzmán-Gutiérrez E, Contreras-Duarte S. et al. Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels. Mol Aspects Med 2017; 55: 26-44
3 Wang J, Li Z, Lin L. Maternal lipid profiles in women with and without gestational diabetes mellitus. Medicine (Baltimore) 2019; 98 (16) e15320
4 Pecks U, Brieger M, Schiessl B. et al. Maternal and fetal cord blood lipids in intrauterine growth restriction. J Perinat Med 2012; 40 (03) 287-296
5 Serizawa K, Ogawa K, Arata N, Ogihara A, Horikawa R, Sakamoto N. Association between low maternal low-density lipoprotein cholesterol levels in the second trimester and delivery of small for gestational age infants at term: a case-control study of the national center for child health and development birth cohort. J Matern Fetal Neonatal Med 2017; 30 (12) 1383-1387
6 Jancevska A, Tasic V, Damcevski N, Danilovski D, Jovanovska V, Gucev Z. Children born small for gestational age (SGA). Prilozi 2012; 33 (02) 47-58
7 Mendez-Figueroa H, Truong VT, Pedroza C, Khan AM, Chauhan SP. Small-for-gestational-age infants among uncomplicated pregnancies at term: a secondary analysis of 9 Maternal-Fetal Medicine Units Network studies. Am J Obstet Gynecol 2016; 215 (05) 628.e1-628.e7
8 Gordijn SJ, Beune IM, Thilaganathan B. et al. Consensus definition of fetal growth restriction: a Delphi procedure. Ultrasound Obstet Gynecol 2016; 48 (03) 333-339
9 Novac MV, Iliescu DG, Tudorache S. et al. Ultrasound evaluation of fetal biometry and Doppler parameters in the third trimester of pregnancy suspected of intrauterine growth restriction. Curr Health Sci J 2018; 44 (01) 23-28
10 Martin-Gronert MS, Ozanne SE. Mechanisms underlying the developmental origins of disease. Rev Endocr Metab Disord 2012; 13 (02) 85-92
11 Woollett LA, Heubi JE. Fetal and Neonatal Cholesterol Metabolism. In: Feingold KR, Anawalt B, Boyce A. et al., eds. Endotext Internet. South Dartmouth, MA: MDText.com, Inc.; 2000
12 Baardman ME, Erwich JJH, Berger RM. et al. The origin of fetal sterols in second-trimester amniotic fluid: endogenous synthesis or maternal-fetal transport?. Am J Obstet Gynecol 2012; 207 (03) 202.e19-202.e25
13 Sreckovic I, Birner-Gruenberger R, Obrist B. et al. Distinct composition of human fetal HDL attenuates its anti-oxidative capacity. Biochim Biophys Acta 2013; 1831 (04) 737-746
14 Scifres CM, Catov JM, Simhan HN. The impact of maternal obesity and gestational weight gain on early and mid-pregnancy lipid profiles. Obesity (Silver Spring) 2014; 22 (03) 932-938
15 Schmid KE, Davidson WS, Myatt L, Woollett LA. Transport of cholesterol across a BeWo cell monolayer: implications for net transport of sterol from maternal to fetal circulation. J Lipid Res 2003; 44 (10) 1909-1918
16 Sales WB, Silleno Junior JD, Kroll C, Mastroeni SS, Silva JC, Mastroeni MF. Influence of altered maternal lipid profile on the lipid profile of the newborn. Arch Endocrinol Metab 2015; 59 (02) 123-128
17 Unterscheider J, Daly S, Geary MP. et al. Predictable progressive Doppler deterioration in IUGR: does it really exist?. Am J Obstet Gynecol 2013; 209 (06) 539.e1-539.e7
18 Yashodha H, Anjum SK. Cord blood lipid profile in late preterm and term neonates. IJCP 2018; 4 (02) 542-546
19 Kramer MS, Kahn SR, Dahhou M. et al. Maternal lipids and small for gestational age birth at term. J Pediatr 2013; 163 (04) 983-988
20 Schaefer-Graf UM, Graf K, Kulbacka I. et al. Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus. Diabetes Care 2008; 31 (09) 1858-1863
21 Kaser S, Ebenbichler CF, Wolf HJ. et al. Lipoprotein profile and cholesteryl ester transfer protein in neonates. Metabolism 2001; 50 (06) 723-728
22 Ramaraj SM, Bharath AP, Sanjay KM. Lipid profile in neonates and its relation with birth weight and gestational age. Indian J Pediatr 2015; 82 (04) 375-377
23 Kitajima M, Oka S, Yasuhi I, Fukuda M, Rii Y, Ishimaru T. Maternal serum triglyceride at 24--32 weeks' gestation and newborn weight in nondiabetic women with positive diabetic screens. Obstet Gynecol 2001; 97 (5, Pt 1): 776-780
24 Ghiasi A, Ziaei S, Faghihzadeh S. The relationship between levels of lipids and lipoprotein b-100 in maternal serum and umbilical cord serum and assessing their effects on newborn infants anthropometric indices. J Midwifery Reprod Health 2014; 2 (04) 227-232
25 Mandraha S, Agrawal A, Talware V. Determination of cord blood lipid profile in neonates and its correlation with birth weight and maternal anthropometry. Indian J Child Health (Bhopal) 2018; 5 (09) 588-591
26 Ramy N, Zakaria M, Kafoury ME, Kamal M. Cord blood lipid profile in relation to anthropometric measures of newborns. Kasr Al Ainy Med J 2017; 23 (01) 54
27 Rodie VA, Caslake MJ, Stewart F. et al. Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. Atherosclerosis 2004; 176 (01) 181-187
28 Ortega RM, Gaspar MJ, Cantero M. Influence of maternal serum lipids and maternal diet during the third trimester of pregnancy on umbilical cord blood lipids in two populations of Spanish newborns. Int J Vitam Nutr Res 1996; 66 (03) 250-257